Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence.

ABSTRACT:

Background

Excessive alcohol use is the third leading cause of preventable death and is highly correlated with alcohol dependence, a heritable phenotype. Many genetic factors for alcohol dependence have been found, but many remain unknown. In search of additional genetic factors, we examined the association between Diagnostic and StatisticalManual of Mental Disorders, Fourth Edition (DSM-IV) alcohol dependence and all common copy number variations (CNVs) with good reliability in the Study of Addiction: Genetics and Environment (SAGE).

Methods

All participants in SAGE were interviewed using the Semi-Structured Assessment for the Genetics of Alcoholism, as a part of 3 contributing studies. A total of 2,610 non-Hispanic European American samples were genotyped on the Illumina H

SUBMITTER: Lin P 

PROVIDER: S-EPMC3436997 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature