A software toolkit and interface for performing stable isotope labeling and top3 quantification using Progenesis LC-MS.

ABSTRACT: Numerous software packages exist to provide support for quantifying peptides and proteins from mass spectrometry (MS) data. However, many support only a subset of experimental methods or instrument types, meaning that laboratories often have to use multiple software packages. The Progenesis LC-MS software package from Nonlinear Dynamics is a software solution for label-free quantitation. However, many laboratories using Progenesis also wish to employ stable isotope-based methods that are not natively supported in Progenesis. We have developed a Java programming interface that can use the output files produced by Progenesis, allowing the basic MS features quantified across replicates to be used in a range of different experimental methods. We have developed post-processing software (the Pro

SUBMITTER: Qi D 

PROVIDER: S-EPMC3437041 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature