Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

ABSTRACT: Amyloid-β (Aβ) peptides and their metal-associated aggregated states have been implicated in the pathogenesis of Alzheimer's disease (AD). Although the etiology of AD remains uncertain, understanding the role of metal-Aβ species could provide insights into the onset and development of the disease. To unravel this, bifunctional small molecules that can specifically target and modulate metal-Aβ species have been developed, which could serve as suitable chemical tools for investigating metal-Aβ-associated events in AD. Through a rational structure-based design principle involving the incorporation of a metal binding site into the structure of an Aβ interacting molecule, we devised stilbene derivatives (L1-a and L1-b) and demonstrated their reactivity toward metal-Aβ species. In particular, th

SUBMITTER: Braymer JJ 

PROVIDER: S-EPMC3437264 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature