Failure to detect significant association between estrogen receptor-alpha gene polymorphisms and endometriosis in Japanese women.

ABSTRACT:

Objectives

The aim of the study was to test whether estrogen receptor 1 (ESR1) gene polymorphisms are correlated with the risk of the development of endometriosis in Japanese women, as a preliminary study.

Methods

To compare allelic frequencies and genotype distributions, a case-control study of 100 affected women and 143 women with no evidence of disease was performed using 10 microsatellite repeat markers and 66 single-nucleotide polymorphisms (SNPs) in the ESR1 gene region.

Results

Although our results might be insufficient to detect genetic susceptibility, owing to the small sample size and low genetic power, statistical analysis of the differences in allelic frequency between the cases and controls at each microsatellite locus demonstrated that no microsatellite

SUBMITTER: Matsuzaka Y 

PROVIDER: S-EPMC3437353 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature