Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks.

ABSTRACT: Alternative inclusion of exons increases the functional diversity of proteins. Among alternatively spliced exons, tissue-specific exons play a critical role in maintaining tissue identity. This raises the question of how tissue-specific protein-coding exons influence protein function. Here we investigate the structural, functional, interaction, and evolutionary properties of constitutive, tissue-specific, and other alternative exons in human. We find that tissue-specific protein segments often contain disordered regions, are enriched in posttranslational modification sites, and frequently embed conserved binding motifs. Furthermore, genes containing tissue-specific exons tend to occupy central positions in interaction networks and display distinct interaction partners in the respective tis

SUBMITTER: Buljan M 

PROVIDER: S-EPMC3437557 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature