Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations.

ABSTRACT: This study was designed to determine the ancestral composition of a multi-ethnic sample collected for studies of drug addictions in New York City and Las Vegas, and to examine the reliability of self-identified ethnicity and three-generation family history data. Ancestry biographical scores for seven clusters corresponding to world major geographical regions were obtained using STRUCTURE, based on genotypes of 168 ancestry informative markers (AIMs), for a sample of 1,291 African Americans (AA), European Americans (EA), and Hispanic Americans (HA) along with data from 1,051 HGDP-CEPH 'diversity panel' as a reference. Self-identified ethnicity and family history data, obtained in an interview, were accurate in identifying the individual major ancestry in the AA and the EA samples (approxima

SUBMITTER: Levran O 

PROVIDER: S-EPMC3437566 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature