The safety and efficacy of sublingual and oral immunotherapy for milk allergy.

ABSTRACT:

Background

Oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) are potential therapies for food allergy, but the optimal method of administration, mechanism of action, and duration of response remain unknown.

Objective

We sought to explore the safety and efficacy of OIT and SLIT for the treatment of cow's milk (CM) allergy.

Methods

We randomized children with CM allergy to SLIT alone or SLIT followed by OIT. After screening double-blind, placebo-controlled food challenges and initial SLIT escalation, subjects either continued SLIT escalation to 7 mg daily or began OIT to either 1000 mg (the OITB group) or 2000 mg (the OITA group) of milk protein. They were challenged with 8 g of milk protein after 12 and 60 weeks of maintenance. If they passed the 60-week cha

SUBMITTER: Keet CA 

PROVIDER: S-EPMC3437605 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature