Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex.

ABSTRACT: A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several decades. We applied voxel-based lesion-symptom mapping in 344 individuals with focal lesions (165 involving the PFC) who had been tested on a comprehensive battery of neuropsychological tasks. Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching), which included the dorsolateral prefrontal cortex and anterior cingulate cortex and a s

SUBMITTER: Glascher J 

PROVIDER: S-EPMC3437894 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature