Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen.

ABSTRACT:

Background

Inflammatory cytokines including the IL-1 family, TNF-alpha and IL-6 mediate the formation of thrombosis on the luminal surface of atherosclerotic plaques. Gene polymorphisms that regulate these cytokines' expression may explain part of the variation in susceptibility to stroke in patients with carotid atherosclerosis. The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis.

Methods

The study included 95 subjects with symptomatic (transient ischaemic attacks or stroke) and 113 subjects with asymptomatic carotid atherosclerotic disease. A panel of evenly spaced SNPs including previously reported functionally significant polymorphisms were geno

SUBMITTER: Belfer I 

PROVIDER: S-EPMC3437928 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature