Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.

ABSTRACT:

Context

Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation.

Objective

To determine whether there would be an interaction between genetic variation in FKBP5 and childhood trauma in predicting aggressive behavior.

Design

Cross-sectional study. Four FKBP5 single-nucleotide polymorphisms used in previous studies (rs3800373, rs9296158, rs1360780, and rs9470080) were genotyped. Three diplotypes were derived from 2 major putatively functional haplotypes regulating protein expression that were previously associated with glucocorticoid receptor sensitivity.

Setting

Penitentiary District of Abruzzo-Molise in central Italy.

Participan

SUBMITTER: Bevilacqua L 

PROVIDER: S-EPMC3437943 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature