Postembryonic neuronal addition in zebrafish dorsal root ganglia is regulated by Notch signaling.

ABSTRACT:

Background

The sensory neurons and glia of the dorsal root ganglia (DRG) arise from neural crest cells in the developing vertebrate embryo. In mouse and chick, DRG formation is completed during embryogenesis. In contrast, zebrafish continue to add neurons and glia to the DRG into adulthood, long after neural crest migration is complete. The molecular and cellular regulation of late DRG growth in the zebrafish remains to be characterized.

Results

In the present study, we use transgenic zebrafish lines to examine neuronal addition during postembryonic DRG growth. Neuronal addition is continuous over the period of larval development. Fate-mapping experiments support the hypothesis that new neurons are added from a population of resident, neural crest-derived progenitor cells. C

SUBMITTER: McGraw HF 

PROVIDER: S-EPMC3438120 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature