Total synthesis of (-)-irciniastatin B and structural confirmation via chemical conversion to (+)-irciniastatin A (psymberin).

ABSTRACT: The total synthesis and structural confirmation of the marine sponge cytotoxin (-)-irciniastatin B has been achieved via a unified strategy employing a late-stage, selective deprotection/oxidation sequence that provides access to both (+)-irciniastatin A (psymberin) and (-)-irciniastatin B.

SUBMITTER: An C 

PROVIDER: S-EPMC3438514 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature