Ontology highlight
ABSTRACT:
SUBMITTER: Buganim Y
PROVIDER: S-EPMC3438668 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Buganim Yosef Y Itskovich Elena E Hu Yueh-Chiang YC Cheng Albert W AW Ganz Kibibi K Sarkar Sovan S Fu Dongdong D Welstead G Grant GG Page David C DC Jaenisch Rudolf R
Cell stem cell 20120901 3
Sertoli cells are considered the "supporting cells" of the testis that play an essential role in sex determination during embryogenesis and in spermatogenesis during adulthood. Their essential roles in male fertility along with their immunosuppressive and neurotrophic properties make them an attractive cell type for therapeutic applications. Here we demonstrate the generation of induced embryonic Sertoli-like cells (ieSCs) by ectopic expression of five transcription factors. We characterize the ...[more]