Asymmetric catalytic synthesis of the proposed structure of trocheliophorolide B.

ABSTRACT: A concise catalytic asymmetric synthesis of the proposed structure of trocheliophorolide B is reported. The synthetic sequence notably features an asymmetric acetaldehyde alkynylation, a Ru-catalyzed alder-ene reaction, and a Zn-ProPhenol ynone aldol condensation. Comparison with the reported data suggests a misassignment of the natural product structure.

SUBMITTER: Trost BM 

PROVIDER: S-EPMC3439167 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature