Genetic predisposition, parity, age at first childbirth and risk for breast cancer.

ABSTRACT:

Background

Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk.

Methods

The Malmö Diet and Cancer Study (MDCS) included 17 035 female participants, from which 728 incident breast cancer cases were matched to 1448 controls. The associations between 14 SNPs and breast cancer risk were investigated in different strata of parity and age at first childbirth. A logistic regression analysis for the per allele risk, adjusted for potential confounders yielded odds ratios (OR)

SUBMITTER: Butt S 

PROVIDER: S-EPMC3439270 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature