MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population.

ABSTRACT:

Background

A recent study investigated the MYLIP region in the Mexican population in order to fine-map the actual susceptibility variants of this locus. The p.N342S polymorphism was identified as the underlying functional variant accounting for one of the previous signals of genome-wide association studies and the N342 allele was associated with higher cholesterol concentrations in Mexican dyslipidemic individuals. To date, there is no further evaluation on this genotype-phenotype association in the literature. In this scenario, and because of a possible pharmacotherapeutic target of dyslipidemia, the main aim of this study was to assess the influence of the MYLIP p.N342S polymorphism on lipid profile in Brazilian individuals.

Methods

1295 subjects of the general population

SUBMITTER: Santos PC 

PROVIDER: S-EPMC3439349 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature