The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes.

ABSTRACT: To investigate the importance of core promoter elements for tissue-specific transcription of RNA polymerase II genes, we examined testis-specific transcription in Drosophila melanogaster. Bioinformatic analyses of core promoter sequences from 190 genes that are specifically expressed in testes identified a 10 bp A/T-rich motif that is identical to the translational control element (TCE). The TCE functions in the 5' untranslated region of Mst(3)CGP mRNAs to repress translation, and it also functions in a heterologous gene to regulate transcription. We found that among genes with focused initiation patterns, the TCE is significantly enriched in core promoters of genes that are specifically expressed in testes but not in core promoters of genes that are specifically expressed in other tissues

SUBMITTER: Katzenberger RJ 

PROVIDER: S-EPMC3439415 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature