The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents.

ABSTRACT:

Context

Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in others.

Objective

To investigate whether the association of tCys with body fat extends to children at particular risk of obesity, and whether tCys is associated with insulin resistance and obesity-associated inflammation.

Methods

We explored the cross-sectional relations of fasting plasma tCys and related metabolites with body composition measured by dual-energy X-ray absorptiometry in 984 Hispanic children and adolescents aged 4-19 years from the Viva La Familia Study. Linear and logistic regression and dose-response curves were used to evaluate relations of

SUBMITTER: Elshorbagy AK 

PROVIDER: S-EPMC3439485 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature