Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis.

ABSTRACT:

Background

Network motifs, recurring subnetwork patterns, provide significant insight into the biological networks which are believed to govern cellular processes.

Methods

We present a comparative network motif experimental approach, which helps to explain complex biological phenomena and increases the understanding of biological functions at the molecular level by exploring evolutionary design principles of network motifs.

Results

Using this framework to analyze the SM (Sec1/Munc18)-SNARE (N-ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. We identify the closed binding mode of neuronal SM (Munc18-1) and

SUBMITTER: Xia T 

PROVIDER: S-EPMC3439672 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature