IPAD: the Integrated Pathway Analysis Database for Systematic Enrichment Analysis.

ABSTRACT:

Background

Next-Generation Sequencing (NGS) technologies and Genome-Wide Association Studies (GWAS) generate millions of reads and hundreds of datasets, and there is an urgent need for a better way to accurately interpret and distill such large amounts of data. Extensive pathway and network analysis allow for the discovery of highly significant pathways from a set of disease vs. healthy samples in the NGS and GWAS. Knowledge of activation of these processes will lead to elucidation of the complex biological pathways affected by drug treatment, to patient stratification studies of new and existing drug treatments, and to understanding the underlying anti-cancer drug effects. There are approximately 141 biological human pathway resources as of Jan 2012 according to the Pathguide data

SUBMITTER: Zhang F 

PROVIDER: S-EPMC3439721 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature