Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects.

ABSTRACT:

Background

The angiotensin converting enzyme 2 (ACE2) G8790A gene polymorphism has been associated with the susceptibility to essential hypertension (EH), but the results are disputable.

Objective and methods

To investigate the relationship between the ACE2 G8790A gene polymorphism and EH, eight separate studies with 5260 subjects were meta-analyzed. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated by a random effect model.

Results

In the ACE2 G8790A gene polymorphism and EH meta-analysis in a Chinese population, no significant association was found between the ACE2 G8790A gene polymorphism and EH (OR: 1.03, 95% CI: 0.87-1.21, P = 0.76). In the stratified analysis by gender, no significant risk was found among males (OR: 1.

SUBMITTER: Li YY 

PROVIDER: S-EPMC3439858 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature