Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei.

ABSTRACT: Trypanosomatid parasites provide an extreme model for the posttranscriptional control of eukaryotic gene expression. However, most analysis of their differential gene regulation has focussed on comparisons between life-cycle stages that exist in the blood of mammalian hosts and tsetse flies, the parasite's vector. These environments differ acutely in their temperature, and nutritional, metabolic and molecular composition. In the bloodstream, however, a more exquisitely regulated developmental step occurs: the production of transmissible stumpy forms from proliferative slender forms. This transition occurs in the relatively homogenous bloodstream environment, with stumpy-specific gene expression being repressed until accumulation of a proposed parasite-derived signal, stumpy induction facto

SUBMITTER: MacGregor P 

PROVIDER: S-EPMC3439917 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature