Prioritizing cancer-related key miRNA-target interactions by integrative genomics.

ABSTRACT: Accumulating evidence indicates that microRNAs (miRNAs) can function as oncogenes or tumor suppressor genes by controlling few key targets, which in turn contribute to the pathogenesis of cancer. The identification of cancer-related key miRNA-target interactions remains a challenge. We performed a systematic analysis of known cancer-related key interactions manually curated from published papers based on different aspects including sequence, expression and function. Known cancer-related key interactions show more miRNA binding sites (especially for 8mer binding sites), more reliable binding of miRNA to the target region, higher expression associations and broader functional coverage when compared to non-disease-related interactions. Through integrating these sequence, expression and functi

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC3439920 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature