Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.

ABSTRACT:

Background

Obesity is a growing worldwide problem with genetic and environmental causes, and it is an underlying basis for many diseases. Studies have shown that the toxicant-activated aryl hydrocarbon receptor (AHR) may disrupt fat metabolism and contribute to obesity. The AHR is a nuclear receptor/transcription factor that is best known for responding to environmental toxicant exposures to induce a battery of xenobiotic-metabolizing genes.

Objectives

The intent of the work reported here was to test more directly the role of the AHR in obesity and fat metabolism in lieu of exogenous toxicants.

Methods

We used two congenic mouse models that differ at the Ahr gene and encode AHRs with a 10-fold difference in signaling activity. The two mouse strains were fed either a l

SUBMITTER: Kerley-Hamilton JS 

PROVIDER: S-EPMC3440132 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature