Population dynamics and genetic diversity of C4 strains of human enterovirus 71 in Mainland China, 1998-2010.

ABSTRACT:

Background

Since 1997, several countries within the Asian Pacific region have been affected by one or more massive outbreaks of Hand Foot and Mouth Disease (HFMD). Virus typing experiments revealed that these outbreaks were caused by strains of human enterovirus 71 (EV71) belonging to several different, recently emerged subgenogroups. In mainland China, a different situation was observed. The first outbreak, localized in Shangdong Province, was reported in 2007, and was followed by a wide-spread outbreak in mainland China in 2008. Since then, numbers of reported HFMD cases have been persistently high.

Methodology/principal findings

To gain insight in the epidemiological behavior of EV71 in China, we studied genetic diversity and EV71 population dynamics to address whether th

SUBMITTER: Guan D 

PROVIDER: S-EPMC3440427 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature