A reanalysis of curvature in the dose response for cancer and modifications by age at exposure following radiation therapy for benign disease.

ABSTRACT:

Purpose

To assess the shape of the dose response for various cancer endpoints and modifiers by age and time.

Methods and materials

Reanalysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by cancer endpoint (stomach, pancreas, lung, leukemia, all other).

Results

There are statistically significant (P<.05) excess risks for all cancer and for lung cancer and borderline statistically significant risks for stomach cancer (P=.07), and leukemia (P=.06), with excess relative risks Gy(-1) of 0.024 (95% confidence interval [CI] 0.011, 0.039), 0.559 (95% CI 0.221, 1.021), 0.042 (95% CI -0.002, 0.119), and 1.087 (95% CI -0.018, 4.925), respectively. There is statistically significant (P=.007) excess risk of pancreatic cancer when adjusted for dose-resp

SUBMITTER: Little MP 

PROVIDER: S-EPMC3440544 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature