Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding.

ABSTRACT:

Background

The inefficiency of HIV breast-milk transmission may be caused by the presence of immunologically active factors, including human milk oligosaccharides (HMOs).

Objective

We investigated whether HMO concentrations are associated with a reduced risk of postnatal HIV transmission.

Design

A nested case-control study was conducted within a larger cohort study of HIV-infected women and their infants followed from birth to 24 mo in Lusaka, Zambia. Breast-milk samples collected at 1 mo from 81 HIV-infected women who transmitted via breastfeeding, a random sample of 86 HIV-infected women who did not transmit despite breastfeeding, and 36 uninfected breastfeeding women were selected. Total and specific HMO concentrations were measured by HPLC and compared between gro

SUBMITTER: Bode L 

PROVIDER: S-EPMC3441110 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature