Transcriptome analysis of microRNAs in developing cerebral cortex of rat.

ABSTRACT:

Background

The morphogenesis of the cerebral cortex depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs and other groups of small RNAs, play profound roles in various physiological and pathological processes via their regulation of gene expression. A systematic analysis of the expression profile of small non-coding RNAs in developing cortical tissues is important for clarifying the gene regulation networks mediating key developmental events during cortical morphogenesis.

Results

Global profiling of the small RNA transcriptome was carried out in rat cerebral cortex from E10 till P28 using next-generation sequencing technique. We found an extraordinary degree of developmental stage-specific expression of a large grou

SUBMITTER: Yao MJ 

PROVIDER: S-EPMC3441217 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature