Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans.

ABSTRACT:

Introduction

Localized Cutaneous Leishmaniasis (LCL) and Mucosal Leishmaniasis (ML) are two extreme clinical forms of American Tegumentary Leishmaniasis that usually begin as solitary primary cutaneous lesions. Host and parasite factors that influence the progression of LCL to ML are not completely understood. In this manuscript, we compare the gene expression profiles of primary cutaneous lesions from patients who eventually developed ML to those that did not.

Methods

Using RNA-seq, we analyzed both the human and Leishmania transcriptomes in primary cutaneous lesions.

Results

Limited number of reads mapping to Leishmania transcripts were obtained. For human transcripts, compared to ML patients, lesions from LCL patients displayed a general multi-polarization of the a

SUBMITTER: Maretti-Mira AC 

PROVIDER: S-EPMC3441406 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature