The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain.

ABSTRACT:

Background

Unlike mammals, zebrafish exhibits extensive neural regeneration after injury in adult stages of its lifetime due to the neurogenic activity of the radial glial cells. However, the genes involved in the regenerative neurogenesis response of the zebrafish brain are largely unknown. Thus, understanding the underlying principles of this regeneration capacity of the zebrafish brain is an interesting research realm that may offer vast clinical ramifications.

Results

In this paper, we characterized the expression pattern of cxcr5 and analyzed the function of this gene during adult neurogenesis and regeneration of the zebrafish telencephalon. We found that cxcr5 was upregulated transiently in the RGCs and neurons, and the expression in the immune cells such as leukocytes

SUBMITTER: Kizil C 

PROVIDER: S-EPMC3441421 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature