MMass as a software tool for the annotation of cyclic peptide tandem mass spectra.

ABSTRACT: Natural or synthetic cyclic peptides often possess pronounced bioactivity. Their mass spectrometric characterization is difficult due to the predominant occurrence of non-proteinogenic monomers and the complex fragmentation patterns observed. Even though several software tools for cyclic peptide tandem mass spectra annotation have been published, these tools are still unable to annotate a majority of the signals observed in experimentally obtained mass spectra. They are thus not suitable for extensive mass spectrometric characterization of these compounds. This lack of advanced and user-friendly software tools has motivated us to extend the fragmentation module of a freely available open-source software, mMass (http://www.mmass.org), to allow for cyclic peptide tandem mass spectra annotati

SUBMITTER: Niedermeyer TH 

PROVIDER: S-EPMC3441486 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature