Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population.

ABSTRACT:

Rationale

Identification and characterization of asthma phenotypes are challenging due to disease complexity and heterogeneity. The Severe Asthma Research Program (SARP) used unsupervised cluster analysis to define 5 phenotypically distinct asthma clusters that they replicated using 3 variables in a simplified algorithm. We evaluated whether this simplified SARP algorithm could be used in a separate and diverse urban asthma population to recreate these 5 phenotypic clusters.

Methods

The SARP simplified algorithm was applied to adults with asthma recruited to the New York University/Bellevue Asthma Registry (NYUBAR) to classify patients into five groups. The clinical phenotypes were summarized and compared.

Results

Asthma subjects in NYUBAR (n = 471) were predominantly

SUBMITTER: Patrawalla P 

PROVIDER: S-EPMC3441500 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature