Transcription factor co-localization patterns affect human cell type-specific gene expression.

ABSTRACT:

Background

Cellular development requires the precise control of gene expression states. Transcription factors are involved in this regulatory process through their combinatorial binding with DNA. Information about transcription factor binding sites can help determine which combinations of factors work together to regulate a gene, but it is unclear how far the binding data from one cell type can inform about regulation in other cell types.

Results

By integrating data on co-localized transcription factor binding sites in the K562 cell line with expression data across 38 distinct hematopoietic cell types, we developed regression models to describe the relationship between the expression of target genes and the transcription factors that co-localize nearby. With K562 binding sit

SUBMITTER: Wang D 

PROVIDER: S-EPMC3441573 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature