Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes.

ABSTRACT:

Background

The human genome contains a large amount of cis-regulatory DNA elements responsible for directing both spatial and temporal gene-expression patterns. Previous studies have shown that based on their mRNA expression breast tumors could be divided into five subgroups (Luminal A, Luminal B, Basal, ErbB2(+) and Normal-like), each with a distinct molecular portrait. Whole genome gene expression analysis of independent sets of breast tumors reveals repeatedly the robustness of this classification. Furthermore, breast tumors carrying a TP53 mutation show a distinct gene expression profile, which is in strong association to the distinct molecular portraits. The mRNA expression of 552 genes, which varied considerably among the different tumors, but little between two samples of th

SUBMITTER: Joshi H 

PROVIDER: S-EPMC3441847 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature