Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China.

ABSTRACT:

Aim

To investigate the contribution of fucosyltransferase 2 (FUT2) variants to the genetic susceptibility and clinical heterogeneity of ulcerative colitis (UC) between Han and Uyghur patients in Xinjiang, China.

Methods

A total of 102 UC patients (53 Han patients including 22 men and 31 women, and 49 Uyghur patients including 25 men and 24 women; aged 48 ± 16 years) and 310 age- and sex-matched healthy controls were enrolled from January 2010 to May 2011 in Xinjiang People's Hospital of China. UC was diagnosed based on the clinical, endoscopic and histological findings following Lennard-Jones criteria. Blood samples were collected and genomic DNA was extracted by the routine laboratory methods. Polymerase chain reaction-sequence-based typing method was used to identify FUT2

SUBMITTER: Aheman A 

PROVIDER: S-EPMC3442215 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature