Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa.

ABSTRACT:

Objectives

High-risk human papillomavirus (HR-HPV) infection is the most common sexually transmitted infection. Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men.

Design

HR-HPV incidence and clearance were evaluated in 999 men (776 HIV-negative and 223 HIV-positive) aged 15-49 years who participated in male circumcision trials in Rakai, Uganda.

Methods

Penile swabs were tested for HR-HPV by Roche HPV Linear Array. A Poisson multivariable model was used to estimate adjusted incidence rate ratios (adjIRRs) and clearance risk ratios (adjRRs).

Results

HR-HPV incidence was 66.5/100 person-years in HIV-positive men and 32.9/100 perso

SUBMITTER: Tobian AA 

PROVIDER: S-EPMC3442933 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature