Comparison of bone marrow and adipose tissue-derived canine mesenchymal stem cells.

ABSTRACT:

Background

Bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose tissue-derived mesenchymal stem cells (AT-MSCs) are potential cellular sources of therapeutic stem cells. MSCs are a multipotent population of cells capable of differentiating into a number of mesodermal lineages. Treatment using MSCs appears to be a helpful approach for structural restoration in regenerative medicine. Correct identification of these cells is necessary, but there is inadequate information on the MSC profile of cell surface markers and mRNA expression in dogs. In this study, we performed molecular characterization of canine BM-MSCs and AT-MSCs using immunological and mRNA expression analysis.

Results

Samples were confirmed to be multipotent based on their osteogenic and adipogenic dif

SUBMITTER: Takemitsu H 

PROVIDER: S-EPMC3442961 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature