Comparison of Atlantic salmon individuals with different outcomes of cardiomyopathy syndrome (CMS).

ABSTRACT:

Background

Cardiomyopathy syndrome (CMS) is a severe disease of Atlantic salmon (Salmo salar L.) associated with significant economic losses in the aquaculture industry. CMS is diagnosed with a severe inflammation and degradation of myocardial tissue caused by a double-stranded RNA virus named piscine myocarditis virus (PMCV), with structural similarities to the Totiviridae family. In the present study we characterized individual host responses and genomic determinants of different disease outcomes.

Results

From time course studies of experimentally infected Atlantic salmon post-smolts, fish exhibited different outcomes of infection and disease. High responder (HR) fish were characterized with sustained and increased viral load and pathology in heart tissue. Low responder (L

SUBMITTER: Timmerhaus G 

PROVIDER: S-EPMC3443006 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature