Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation.

ABSTRACT:

Background

Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (PRRSV) infection could activate NF-κB in MARC-145 cells and alveolar macrophages. The nucleocapsid (N) protein was identified as an NF-κB activator among the structural proteins encoded by PRRSV; however, it remains unclear whether the nonstructural proteins (Nsps) contribute to NF-κB activation. In this study, we identified which Nsps can activate NF-κB and investigated the potential mechanism(s) by which they act.

Results

By screening the individual Nsps of P

SUBMITTER: Fang Y 

PROVIDER: S-EPMC3443020 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature