A genome-scale metabolic model of the lipid-accumulating yeast Yarrowia lipolytica.

ABSTRACT:

Background

Yarrowia lipolytica is an oleaginous yeast which has emerged as an important microorganism for several biotechnological processes, such as the production of organic acids, lipases and proteases. It is also considered a good candidate for single-cell oil production. Although some of its metabolic pathways are well studied, its metabolic engineering is hindered by the lack of a genome-scale model that integrates the current knowledge about its metabolism.

Results

Combining in silico tools and expert manual curation, we have produced an accurate genome-scale metabolic model for Y. lipolytica. Using a scaffold derived from a functional metabolic model of the well-studied but phylogenetically distant yeast S. cerevisiae, we mapped conserved reactions, rewrote gene asso

SUBMITTER: Loira N 

PROVIDER: S-EPMC3443063 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature