Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cells.

ABSTRACT: Environmental chemicals and radiation have often been implicated in producing alterations of the epigenome thus potentially contributing to cancer and other diseases. Ionizing radiation, released during accidents at nuclear power plants or after atomic bomb explosions, is a potentially serious health threat for the exposed human population. This type of high-energy radiation causes DNA damage including single- and double-strand breaks and induces chromosomal rearrangements and mutations, but it is not known if ionizing radiation directly induces changes in the epigenome of irradiated cells. We treated normal human fibroblasts and normal human bronchial epithelial cells with different doses of γ-radiation emitted from a cesium 137 ((137)Cs) radiation source. After a seven-day recovery perio

SUBMITTER: Lahtz C 

PROVIDER: S-EPMC3443085 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature