Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation.

ABSTRACT:

Background

Growth hormone (GH) stimulates whole-body lipid oxidation, but its regulation of muscle lipid oxidation is not clearly defined. Mice with a skeletal muscle-specific knockout of the GH receptor (mGHRKO model) are protected from high fat diet (HFD)-induced insulin resistance and display increased whole-body carbohydrate utilization. In this study we used the mGRHKO mice to investigate the role of muscle GHR signaling on lipid oxidation under regular chow (RC)- and HFD- fed conditions, and in response to fasting.

Methodology/principal findings

Expression of lipid oxidation genes was analyzed by real-time PCR in the muscles of RC- and HFD- fed mice, and after 24 h fasting in the HFD-fed mice. Expression of lipid oxidation genes was lower in the muscles of the mGHRKO m

SUBMITTER: Vijayakumar A 

PROVIDER: S-EPMC3443095 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature