Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness.

ABSTRACT: A fundamental question in molecular evolution is how proteins can adapt to new functions while being conserved for an existing function at the same time. Several theoretical models have been put forward to explain this apparent paradox. The most popular models include neofunctionalization, subfunctionalization (SUBF) by degenerative mutations, and dosage models. All of these models focus on adaptation after gene duplication. A newly proposed model named "Escape from Adaptive Conflict" (EAC) includes adaptive processes before and after gene duplication that lead to multifunctional proteins, and divergence (SUBF). Support for the importance of multifunctionality for the evolution of new protein functions comes from two experimental observations. First, many enzymes have highly evolvable prom

SUBMITTER: Sikosek T 

PROVIDER: S-EPMC3443171 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature