GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum.

ABSTRACT: Glucose-regulated protein 94 is the HSP90-like protein in the lumen of the endoplasmic reticulum and therefore it chaperones secreted and membrane proteins. It has essential functions in development and physiology of multicellular organisms, at least in part because of this unique clientele. GRP94 shares many biochemical features with other HSP90 proteins, in particular its domain structure and ATPase activity, but also displays distinct activities, such as calcium binding, necessitated by the conditions in the endoplasmic reticulum. GRP94's mode of action varies from the general HSP90 theme in the conformational changes induced by nucleotide binding, and in its interactions with co-chaperones, which are very different from known cytosolic co-chaperones. GRP94 is more selective than many o

SUBMITTER: Marzec M 

PROVIDER: S-EPMC3443595 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature