Estrogen receptor genes variations and breast cancer risk in Iran.

ABSTRACT: Evidence suggests that alterations in estrogen signaling pathways, including estrogen receptor α (ER-α) and estrogen receptor β (ER-β) occur during breast cancer development. ER-α and ER-β genes polymorphisms have been found to be associated with breast cancer and clinical features of the disease in the western countries. In the current study, we evaluated the hypothesis that certain sequence variants of the ER-α and ER-β genes are associated with an additively increased risk for breast cancer in Iranian women breast cancer patients. The genes were scanned in 150 Iranian patients with newly diagnosed invasive breast tumors and in healthy control individuals by PCR single-strand conformation polymorphism (SSCP) method. Three single nucleotide polymorphisms (SNPs) in codon10 (TCT→TCC), codon

SUBMITTER: Abbasi S 

PROVIDER: S-EPMC3443893 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature