Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

ABSTRACT:

Background

Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Osteoarthritis has a strong genetic component but the success of previous genetic studies has been restricted due to insufficient sample sizes and phenotype heterogeneity.

Methods

We undertook a large genome-wide association study (GWAS) in 7410 unrelated and retrospectively and prospectively selected patients with severe osteoarthritis in the arcOGEN study, 80% of whom had undergone total joint replacement, and 11,009 unrelated controls from the UK. We replicated the most promising signals in an independent set of up to 7473 cases

SUBMITTER: arcOGEN Consortium 

PROVIDER: S-EPMC3443899 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature