Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B.

ABSTRACT:

Background

Adefovir and tenofovir are nucleotide analogues used as long-term therapy of chronic hepatitis B. Side effects are few, but prolonged and high-dose therapy has been associated with proximal renal tubular dysfunction (RTD).

Aim

To assess the incidence of RTD during long-term nucleotide therapy of chronic hepatitis B.

Methods

A total of 51 patients being treated at the Clinical Center, National Institutes of Health were studied. Diagnosis of RTD required de novo appearance of at least three of five features: hypophosphataemia, hypouricaemia, serum creatinine elevation, proteinuria or glucosuria.

Results

Among 51 patients treated for 1-10 (mean 7.4) years with adefovir (n = 42), tenofovir (n = 4) or adefovir followed by tenofovir (n = 5), 7 (14%) develo

SUBMITTER: Gara N 

PROVIDER: S-EPMC3443969 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature