Use of population based background rates of disease to assess vaccine safety in childhood and mass immunisation in Denmark: nationwide population based cohort study.

ABSTRACT:

Objectives

To predict the number of selected outcomes temporally associated but not caused by vaccination, to aid causality assessment of adverse events arising after mass immunisation in a paediatric population.

Design

Nationwide population based cohort study.

Setting

Denmark.

Participants

All liveborn infants delivered after 1 January 1980. Study population was followed from date of birth until hospital admission for selected outcome diagnoses, death, first emigration, age 18 years, or 31 December 2009. The study population was subject to vaccines used in standard childhood immunisation in Denmark, with 82-93% vaccine coverage.

Main outcome measures

Incidence of acute infectious and post-infectious polyneuritis (Guillain-Barré syndrome), acute transver

SUBMITTER: Rasmussen TA 

PROVIDER: S-EPMC3444137 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature