In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2).

ABSTRACT: Streptomyces coelicolor is the prototype for the investigation of antibiotic-producing and differentiating actinomycetes. As soil bacteria, streptomycetes can metabolize a wide variety of carbon sources and are hence vested with various specific permeases. Their activity and regulation substantially determine the nutritional state of the cell and, therefore, influence morphogenesis and antibiotic production. We have surveyed the genome of S. coelicolor A3(2) to provide a thorough description of the carbohydrate uptake systems. Among 81 ATP-binding cassette (ABC) permeases that are present in the genome, we found 45 to encode a putative solute binding protein, an essential feature for carbohydrate permease function. Similarity analysis allowed the prediction of putative ABC systems for tran

SUBMITTER: Bertram R 

PROVIDER: S-EPMC344420 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature