Non-invasive breath analysis of pulmonary nodules.

ABSTRACT:

Introduction

The search for non-invasive diagnostic methods of lung cancer (LC) has led to new avenues of research, including the exploration of the exhaled breath. Previous studies have shown that LC can, in principle, be detected through exhaled-breath analysis. This study evaluated the potential of exhaled-breath analysis for the distinction of benign and malignant pulmonary nodules (PNs).

Methods

Breath samples were taken from 72 patients with PNs in a prospective trial. Profiles of volatile organic compounds were determined by (1) gas chromatography/mass spectrometry (GC-MS) combined with solid-phase microextraction and (2) a chemical nanoarray.

Results

Fifty-three PNs were malignant and 19 were benign with similar smoking histories and comorbidities. Nodule size

SUBMITTER: Peled N 

PROVIDER: S-EPMC3444531 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature